Anti-tumor Effect of Resveratrol2010-02-12
Since the discovery of resveratrol in wine in 1992, the research has been intensified. In 1993 research on the inhibitory effect of resveratrol on tumor-related kinases showed the suppressive function on proliferation of murine leukocytes, however not much attention was given.(http://pubs.acs.org/doi/abs/10.1021/np50100a021)
In 1997, Jang et al. reported the anti-tumore activity of resveratrol in all the three stages of tumor development, initiation, promotion, progression. The discovery finally drew crowd’s attention. Since then, there has been an ongoing research on this area. By end of June 2009, there are about 15,000 academic publications on the anti-tumor effects of resveratrol. Research has shown that resveratrol has multiple functions to regulate, inhibit and destroy tumor cells, including inducing the apoptosis of tumor cells, inhibit genetic mutations, alter the gene expression, regulate immune system, and inhibit angiogenesis.
Below lists 10 representative relevant papers.
★ Jang M，Cai L, et a1．Cancer chemopreventive activity of resveratrol, a natural product derived from grapes．Science 1997；275(5297)：218-220. (http://www.chiroonline.net/_fileCabinet/scienceresveratrol.pdf)
★ Clement MV, et al. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor. Blood 1998; 92: 996-1002. (http://bloodjournal.hematologylibrary.org/cgi/reprint/92/3/996.pdf)
★ Kimura Y & Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 2001; 131:1844-1849. (http://jn.nutrition.org/cgi/reprint/131/6/1844)
★ Brakenhielm E, et al. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. The FASEB J 2001; 15:1798-1800. (http://www.fasebj.org/cgi/reprint/15/10/1798 )
★ Gao XH, et al. Disparate in vitro and in vivo anti-leukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J. Nutr. 2002; 132: 2076-2081. (http://jn.nutrition.org/cgi/reprint/132/7/2076)
★ Tseng SH, et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clinical Cancer Research 2004; 10:2190-2202. (http://clincancerres.aacrjournals.org/cgi/reprint/10/6/2190)
★ Sunita B. et al. Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev 2005; 14: 596–604. (http://cebp.aacrjournals.org/cgi/reprint/14/3/596)
★ Kotha A, et al. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 2006; 5(3): 621-629. (http://mct.aacrjournals.org/content/5/3/621.full.pdf)
★ Su JL, et al. Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol J. Biol. Chem. 2007; 282: 19385 - 19398. (http://www.jbc.org/cgi/reprint/282/27/19385)
★ Byun HS, et al. Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes. Rheumatology 2008; 47: 301-308. (http://rheumatology.oxfordjournals.org/cgi/reprint/47/3/301)
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