Metabolism of Resveratrol in Human Body2010-02-12
Daily consumption of high concentration resveratrol (0.5, 1, 2.5 and 5g) did not cause adverse effects, However it was converted rapidly into conjugated metabolites in the liver and intestine.
★ Boocock DJ, et al. Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent.
Cancer Epidemiol Biomarkers Prev 2007;16(6):1246–52. (http://cebp.aacrjournals.org/cgi/reprint/16/6/1246)
Therefore, even though you are consuming high dosage of resveratrol every day; the systemic availability of parent resveratrol still remained very low. It is lower than the amount used in the cancer research studies. However, we can observe resveratrol metabolites engage biochemical mechanisms germane to cancer chemoprevention. Below shows some of the latest publications related to resveratrol metabolism and absorption in animal studies.
- ★ Andlauer W, et al. Assessment of resveratrol bioavailability in the perfused small intestine of the rat. Drugs Exp. Clin. Res.2000; 26: 47–55. （http://cat.inist.fr/?aModele=afficheN&cpsidt=1405444）
- ★ De Santi, C et al. Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica. 2000; 30: 609-17. （http://www.informaworld.com/smpp/ftinterface?content=a713868806&rt=0&format=pdf）
- ★ Soleas GJ, et al. Absorption of trans-resveratrol in rats. Methods Enzymol. 2001; 335: 145–154. （http://www.ncbi.nlm.nih.gov/pubmed/11400363） Yu CW, et al. Human, rat, and mouse metabolism of resveratrol. Pharm. Res., 2002; 19: 1907–1914. （http://www.springerlink.com/content/q4p1w8x132042r55/）
- ★ Vitrac X, et al. Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci. 2003; 72: 2219–2233.
According to the clinical trials conducted by National Cancer Institute (NCI), U.S. National Institute of Health in 2007; resveratrol is absorbed into the body through the biliary cycle (bile circulation). In approximately an hour, administration of resveratrol in humans yielded significantly higher concentrations of its metabolites, mainly resveratrol glucuronide which is above 20 times higher concentration than resveratrol ; followed by resveratrol-3-sulphate which near 10 times concentration.