GOLDEN LYPRES ,
Natural antioxidant
Lycopene & Resveratrol

Lycopene Protects Human Prostate

2010-02-12

Prostate gland is a particular organ of males. It was found in the prostate, lycopene concentration is higher than other carotenoids. Therefore, studies on the effect of lycopene in protecting human prostate were developed widely around the world.  Lycopene’s excellent antioxidative effect reduces the occurrence or progression of prostate cancer among men. Clinical and statistical studies pointed that the incidence rate of man prostate cancer in Italy is lower compared to other counties because of the high dietary consumption of tomato products in Italy. Early in 1995, the researchers from Harvard Medical School found an inverse association of intake of carotenoids with risk of prostate cancer, and the major functioning compound is lycopene rather than other carotenoids.

 

  • ★ Giovannucci E, et al. Intake of carotenoids and Retinol in Relation to Risk of Prostate Cancer. J. Natl. Cancer Inst. 1995; 87: 1767-1776. (http://jnci.oxfordjournals.org/cgi/content/abstract/87/23/1767 )
  • ★ Gann PH, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels. Cancer Res 1999; 59: 1225-1230. (http://cancerres.aacrjournals.org/cgi/reprint/59/6/1225 )
  • ★ Kotake-Nara K, et al. Carotenoids affect proliferation of human prostate cancer cells. J Nutr. 2001; 131:3303-3306. (http://jn.nutrition.org/cgi/content/abstract/131/12/3303)
  • ★ Giovannucci E. A review of epidemiologic studies of tomatoes, Lycopene, and prostate cancer. Exp. Biol. Med. 2002; 227: 852-859. (http://www.ebmonline.org/cgi/reprint/227/10/852 )

 

 The growth of human prostate epithelial cells causes prostate enlargement. It was reported that lycopene inhibits the growth of normal human prostate epithelial cells, and eventually releases the urination problem caused by prostate enlargement.

 

  • ★ Obermuller-Jevic UC, et al. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J. Nutr. 2003; 133: 3356 – 3360. (http://jn.nutrition.org/cgi/reprint/133/11/3356 )
  • ★ Liu XX, et al. Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells. Carcinogenesis 2008; 29: 816-823. (http://carcin.oxfordjournals.org/cgi/reprint/29/4/816)

 

 Recently, a clinical study investigated the effects of lycopene supplementation in elderly men diagnosed with benign prostate hyperplasia (BPH). The result of this clinical data directly proved that lycopene inhibited progression of BPH.

  • ★ Schwarz S, et al. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J. Nutr. 2008; 138: 49–53. (http://jn.nutrition.org/cgi/reprint/138/1/49 )